The Autologous bone marrow aspirate concentrate injection for the treatment of osteoarthritis: a randomized controlled trial, Ibn-Sina Hospital, NCT05193877 (US registered clinical trial) Autologous bone marrow aspirate concentrate injection for the treatment of osteoarthritis
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Abstract
Osteoarthritis (OA) is a progressive condition causing symptomatic arthritis in males and females over 45 years, manifested by pain and loss of joint function. The regenerative therapy carry a new insight for treating many orthopedic and sports problems with minimally invasive procedures to treat osteoarthritis. The bone marrow aspirate concentrate is a possible biological treatment for symptomatic osteoarthritis and chondral defects. Consequently, this study aims to investigate the impact of injection of autologous bone marrow aspirate in the treatment of symptomatic knee osteoarthritis, in addition to assess safety, pain, and functional changes. The current study comprised a randomized controlled trial (RCT) to assess the efficacy of autologous bone marrow aspirate concentrate in the treatment of symptomatic knee OA in 30 patients with 55 joints. Two injections were used within 2 months apart. The current results showed a marked drop in the WOMAC score in the intervention arm before and after the injection compared to the control (P-value=0.0001). In conclusion, an improvement of pain and knee function was seen after bone marrow mesenchymal cell injection. The authors recommend extending the following study and treating more patients with knee osteoarthritis with mesenchymal stem cells.
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