Revolutionizing Healthcare with Biomedical Physics and Nanotechnology; A narrative review Revolutionizing Healthcare and Nanotechnology review
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Abstract
Nanotechnology is first proposed in 1959, and it explains the manipulation of materials at microscopic scales. The increasing use of new technologies is leading to a fundamental revolution in the healthcare sector. Recently, nanotechnology, its applications have had a major impact on modern medicine. This review focuses on nanotechnology and its roles and applications in improving medical diagnostics, reducing side effects from targeted therapies, addressing major issues and supporting the development of custom and cost-effective healthcare solutions. A full electronic search in multiple databases like PubMed, and Cochrane were done. Relevant publications on nanotechnology revolutionizing in healthcare mostly in biological physics were collected and analyzed. The current review showed that nanoparticles are used in drug delivery systems, enabling personalized medicine by targeting the particular regions, such as the blood-brain barrier. Magnetic nanoparticles for brain tumor targeting and smart nanoparticles for intracellular delivery are two important innovations. In order to develop medical technologies and treatments, nanotechnology focus on a multidisciplinary such as biology and chemistry. Nanotechnology use several approaches included design, creation, and applications. In conclusion, this study indicated that combining biomedical physics and nanotechnology might improve medicine efficiently, contribute to more effective patient treatment and healing. Additionally, it provides a new technique for making medicine more personalized in the future.
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References
1. Hassan AA, Ali MEM, Abdel-Latif SA, Hasani IW, Fahim YA. Efficient removal of Remazol Red dye from aqueous solution using magnetic nickel ferrite nanoparticles synthesized via aqueous reflux. Sci Rep. 2025;15(1):17527. doi:10.1038/s41598-025-98478-y.
2. Starko I, Tatarchuk T, Naushad M. The potential of Gd doping as a promising approach for enhancing the adsorption properties of nickel–cobalt ferrites. Environ Sci Pollut Res. 2024;31(43):55462-55474. doi:10.1007/s11356-024-34809-2.
3. Malik S, Muhammad K, Waheed Y. Nanotechnology: A revolution in modern industry. Molecules. 2023;28(2):661. doi:10.3390/molecules28020661.
4. Brenner S. Nanomedicine: promises and challenges for the future of public health. Int J Nanomedicine. 2010;5:803-809. doi:10.2147/IJN.S13816.
5. Conte R, Foggia R, Valentino A, Di Salle A, Kandsi F, Calarco A. Nanotechnology advancements transforming molecular diagnostics: applications in precision healthcare. Int J Nano Dimens. 2024;15(3):1-15.
6. Wong IY, Bhatia SN, Toner M. Nanotechnology: emerging tools for biology and medicine. Genes Dev. 2013;27(22):2397-2408. doi:10.1101/gad.226837.113.
7. Fahim YA, Ragab WM, Hasani IW, El-Khawaga AM. Biomedical and environmental applications via nanobiocatalysts and enzyme immobilization. Eur J Med Res. 2025;30(1):505. doi:10.1186/s40001-025-02453-9.
8. Rokunuzzaman MK. The nanotech revolution: advancements in materials and medical science. J Adv Mater Eng. 2024;9(2):1-10.https://matjournals.net/engineering/index.php/JoAME/article/view/578
9. Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. 2018;16(1):71. doi:10.1186/s12951-018-0392-8.
10. Ferraris C, Cavalli R, Panciani PP, Battaglia L. Overcoming the blood-brain barrier: successes and challenges in developing nanoparticle-mediated drug delivery systems for the treatment of brain tumours. Int J Nanomedicine. 2020;15:2999-3022. doi:10.2147/IJN.S231738.
11. Iqbal HMN, Rodriguez AMV, Khandia R, Munjal A, Dhama K. Recent trends in nanotechnology-based drugs and formulations for targeted therapeutic delivery. Recent Pat Inflamm Allergy Drug Discov. 2016;10(2):86-93. doi:10.2174/1872213X10666161213163305.
12. Kazi RNA, Hasani IW, Khafaga DSR, Kabba S, Farhan M, Aatif M, Muteeb G, Fahim YA. Nanomedicine: the effective role of nanomaterials in healthcare from diagnosis to therapy. Pharmaceutics. 2025;17(8):987. doi:10.3390/pharmaceutics17080987.
13. Suhag D, Thakur P, Thakur A. Future perspectives of nanobiology. In: Advancements in Nanobiology. Boca Raton: CRC Press; 2025. p. 345-361.
14. Shivakumar N. Recent advances in biological nanodevices and biosensors: insights into applications and technological innovations. Malaysian Nano Int J. 2024;4(1):86-101.
15. Hameed AAA, Ibrahim IM, Mohammad JF. Fabrication and study of the optical and structural properties of SnO2 thin films as efficient UV detectors. J Opt. 2025;1-10. doi:10.1007/s12596-025-02018-7.
16. Mabrouk M, Das DB, Salem ZA, Beherei HH. Nanomaterials for biomedical applications: production, characterisations, recent trends and difficulties. Molecules. 2021;26(4):1077. doi:10.3390/molecules26041077.
17. Taha SK, Jasim RH, Yaseen AA, Noori FTM. Bactericidal effect of silver nano-coating on Pseudomonas aeruginosa bacteria. In: AIP Conference Proceedings. Melville: AIP Publishing; 2026.
18. Shahbazi-Gahrouei D, Moradi Khaniabadi P, Moradi Khaniabadi B, Shahbazi-Gahrouei S. Medical imaging modalities using nanoprobes for cancer diagnosis: a literature review on recent findings. J Res Med Sci. 2019;24(1):38. doi:10.4103/jrms.JRMS_888_18.
19. Mirza Z, Karim S. Nanoparticles-based drug delivery and gene therapy for breast cancer: recent advancements and future challenges. Semin Cancer Biol. 2021;69:226-237. doi:10.1016/j.semcancer.2020.05.020.
20. Ma X, Tian Y, Yang R, Wang H, Allahou LW, Chang J, Williams G, Knowles JC, Poma A. Nanotechnology in healthcare, and its safety and environmental risks. J Nanobiotechnol. 2024;22(1):715. doi:10.1186/s12951-024-02901-x.
21. Cabral H, Li J, Miyata K, Kataoka K. Controlling the biodistribution and clearance of nanomedicines. Nat Rev Bioeng. 2024;2(3):214-232. doi:10.1038/s44222-023-00138-1.
22. Xu B, Li S, Shi R, Liu H. Multifunctional mesoporous silica nanoparticles for biomedical applications. Signal Transduct Target Ther. 2023;8(1):435. doi:10.1038/s41392-023-01654-7.
23. Dash S, Das T, Patel P, Panda PK, Suar M, Verma SK. Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases. J Nanobiotechnol. 2022;20(1):393. doi:10.1186/s12951-022-01595-3.
24. Abbasi R, Shineh G, Mobaraki M, Doughty S, Tayebi L. Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review. J Nanopart Res. 2023;25(3):43. doi:10.1007/s11051-023-05690-w.
25. Zhang P, Ye G, Xie G, Lv J, Zeng X, Jiang W. Research progress of nanomaterial drug delivery in tumor targeted therapy. Front Bioeng Biotechnol. 2023;11:1240529. doi:10.3389/fbioe.2023.1240529.
26. Kumar RR, Krishnan K, Burle GS, Samathoti P, Pavan Kumar J, Bagade OM, Kumar Reddy KT, Jahnavi P. Biochemical engineering of green nanomaterials for targeted drug delivery and therapeutic applications. J Chem Rev. 2025;7(2):191-215. doi:10.48309/jcr.2025.505263.1413.
27. Yan Y, Sun W, Wei Y, Liu K, Ma J, Hu G. Review of biomass-derived carbon nanomaterials—from 0D to 3D—for supercapacitor applications. Nanomaterials. 2025;15(4):315. doi:10.3390/nano15040315.
28. Pant A, Mackraj I, Govender T. Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology. J Biomed Sci. 2021;28(1):6. doi:10.1186/s12929-020-00698-y.
29. Babu A, Templeton AK, Munshi A, Ramesh R. Nanodrug delivery systems: a promising technology for detection, diagnosis, and treatment of cancer. AAPS PharmSciTech. 2014;15(3):709-721. doi:10.1208/s12249-014-0093-8.
30. Akhtar ZB, Das Gupta A. Advancements within molecular engineering for regenerative medicine and biomedical applications: an investigation analysis towards a computing retrospective. J Electron Electromed Eng Med Inform. 2024;6(1):54-72.
31. Sayed N, Allawadhi P, Khurana A, Singh V, Navik U, Pasumarthi SK, Khurana I, Banothu AK, Weiskirchen R, Bharani KK. Gene therapy: comprehensive overview and therapeutic applications. Life Sci. 2022;294:120375. doi:10.1016/j.lfs.2022.120375.
32. Mukherjee S, Suleman S, Pilloton R, Narang J, Rani K. State of the art in smart portable, wearable, ingestible and implantable devices for health status monitoring and disease management. Sensors. 2022;22(11):4228. doi:10.3390/s22114228.
33. Ahmad MY, Liu S, Tegafaw T, Al Saidi AKA, Zhao D, Liu Y, Nam SW, Chang Y, Lee GH. Heavy metal-based nanoparticles as high-performance X-ray computed tomography contrast agents. Pharmaceuticals. 2023;16(10):1463. doi:10.3390/ph16101463.
34. Ibrahim YO, Maalej N, Pirzada BM, Raja AY, Anjum DH, Jan N, Behouch A, Qurashi AH. Gold nanoparticles spectral CT imaging and limit of detectability in a new materials contrast-detail phantom. Phys Med. 2024;120:103326. doi:10.1016/j.ejmp.2024.103326.
35. Uritu CM, Al-Matarneh CM, Bostiog DI, Coroaba A, Ghizdovat V, Filipiuc SI, Simionescu N, Stefanescu C, Jalloul W, Nastasa V. Radiolabeled multi-layered coated gold nanoparticles as potential biocompatible PET/SPECT tracers. J Mater Chem B. 2024;12(15):3659-3675. doi:10.1039/D3TB02761A.
36. Lin Z, Zhao Z, Lin X, Yang Z, Wang L, Xi R, Long D. Advances in oral treatment of inflammatory bowel disease using protein-based nanoparticle drug delivery systems. Drug Deliv. 2025;32(1):2544689. doi:10.1080/10717544.2025.2544689.
37. Zhang W, Liu H, Qiu X, Zuo F, Wang B. Mesoporous silica nanoparticles as a drug delivery mechanism. Open Life Sci. 2024;19(1):1-15. doi:10.1515/biol-2022-0867.
38. Sun L, Liu H, Ye Y, Lei Y, Islam R, Tan S, Tong R, Miao YB, Cai L. Smart nanoparticles for cancer therapy. Signal Transduct Target Ther. 2023;8(1):418. doi:10.1038/s41392-023-01642-x.
39. Stojanov S, Berlec A. Smart bionanomaterials for treatment and diagnosis of inflammatory bowel disease. Nanotechnol Rev. 2024;13(1):1-18. doi:10.1515/ntrev-2024-0057.
40. Kumar R, Pulikanti GR, Shankar KR, Rambabu D, Mangili V, Kumbam LR, Sagara PS, Nakka N, Yogesh M. Surface coating and functionalization of metal and metal oxide nanoparticles for biomedical applications. In: Mondal K, editor. Metal Oxides for Biomedical and Biosensor Applications. Amsterdam: Elsevier; 2022. p. 205-231.
41. Barua S, Mitragotri S. Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects. Nano Today. 2014;9(2):223-243. doi:10.1016/j.nantod.2014.04.008.
42. Wang B, Hu S, Teng Y, Chen J, Wang H, Xu Y, Wang K, Xu J, Cheng Y, Gao X. Current advance of nanotechnology in diagnosis and treatment for malignant tumors. Signal Transduct Target Ther. 2024;9(1):200. doi:10.1038/s41392-024-01889-y.
43. Wani SUD, Ali M, Masoodi MH, Khan NA, Zargar MI, Hassan R, Mir SA, Gautam SP, Gangadharappa HV, Osmani RAM. A review on nanoparticles categorization, characterization and applications in drug delivery systems. Vib Spectrosc. 2022;121:103407. doi:10.1016/j.vibspec.2022.103407.
44. Heidari A, Mohammadi J, Ghodousi M, Mahmoodi M, Ebrahimi S, Pishbin E, Rahdar A. Metal-based nanoparticle in cancer treatment: lessons learned and challenges. Front Bioeng Biotechnol. 2024;12:1436297. doi:10.3389/fbioe.2024.1436297.
45. Eleraky MI, Razek TMA, Hasani IW, Fahim YA. Adsorptive removal of lead, copper, and nickel using natural and activated Egyptian calcium bentonite clay. Sci Rep. 2025;15(1):13050. doi:10.1038/s41598-025-95184-7.
46. Idrees H, Zaidi SZJ, Sabir A, Khan RU, Zhang X, Hassan SU. A review of biodegradable natural polymer-based nanoparticles for drug delivery applications. Nanomaterials. 2020;10(10):1970. doi:10.3390/nano10101970.
47. Jiao M, Zhang P, Meng J, Li Y, Liu C, Luo X, Gao M. Recent advancements in biocompatible inorganic nanoparticles towards biomedical applications. Biomater Sci. 2018;6(4):726-745. doi:10.1039/C7BM01020F.
48. Ayanda OS, Mmuoegbulam AO, Okezie O, Iya NID, Mohammed SE, James PH, Muhammad AB, Unimke AA, Alim SA, Yahaya SM, Ojo A, Adaramoye TO, Ekundayo SK, Abdullahi A, Badamasi H. Recent progress in carbon-based nanomaterials: critical review. J Nanopart Res. 2024;26(5):106. doi:10.1007/s11051-024-06006-2.
49. Eker F, Duman H, Akdaş E, Bolat E, Sarıtaş S, Karav S, Witkowska AM. A comprehensive review of nanoparticles: from classification to application and toxicity. Molecules. 2024;29(15):3482. doi:10.3390/molecules29153482.
50. Karnwal A, Jassim AY, Mohammed AA, Sharma V, Al-Tawaha ARMS, Sivanesan I. Nanotechnology for healthcare: plant-derived nanoparticles in disease treatment and regenerative medicine. Pharmaceuticals. 2024;17(12):1711. doi:10.3390/ph17121711.
51. Zhang L, Webster TJ. Nanotechnology and nanomaterials: promises for improved tissue regeneration. Nano Today. 2009;4(1):66-80. doi:10.1016/j.nantod.2008.10.014.
52. Padmanabhan P, Kumar A, Kumar S, Chaudhary RK, Gulyás B. Nanoparticles in practice for molecular-imaging applications: an overview. Acta Biomater. 2016;41:1-16. doi:10.1016/j.actbio.2016.06.003.
53. Mubeen B, Ansar AN, Rasool R, Ullah I, Imam SS, Alshehri S, Ghoneim MM, Alzarea SI, Nadeem MS, Kazmi I. Nanotechnology as a novel approach in combating microbes providing an alternative to antibiotics. Antibiotics (Basel). 2021;10(12):1473. doi:10.3390/antibiotics10121473.