Partial healing of congenital palmoplantar keratoderma with autologous bone marrow cells. congenital palmoplantar keratoderma with autologous bone marrow cells.
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Abstract
Abstract
Palmoplantar keratoderma is a disease characterized by excessive thickening of the epidermis in palms and soles. The disease can be hereditary or acquired at the early onset of the disease, and the involvement of many family members points to the congenital type. In addition, many congenital cases harbor additional phenotypic manifestations. Hereby, we report an 11-year-old male patient with early onset palmoplantar keratoderma associated with woolly hair. The combination of palmoplantar keratoderma and woolly hair is uncommon. It has been reported as part of the Naxos and the Carvajal syndrome, both caused by mutation in desmosomal proteins and sometimes cardiomyopathy, but not in our case. The patient experienced prolonged remission of his symptoms with autologous bone marrow-derived mononuclear cell infusion. The current technique can be used as one treatment strategy in such cases.
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