Impact of the Immunohistochemistry on appraisal of Oral Squamous Cell Carcinoma and Cervical Lymph Nodes Metastasis Impact of the Immunohistochemistry on appraisal of Oral Squamous Cell Carcinoma and Cervical Lymph Nodes Metastasis

Article Sidebar

PDF
Published: Aug 31, 2024
DOI: https://doi.org/10.58564/jmob.49
Keywords:
biomarkers, IHC, Squamous Cell Carcinoma, Tumor

Main Article Content

Abdulazeez Muayad Abdulkarem
Lecturer, Department of Oral and Maxillofacial Surgery, College of Dentistry, University of ALMuthaana/ Iraq.
Sabah Abdulaziz Issa
Consultant, Department of Maxillofacial Sugery/ Ghazi Al-Hariri Hospital for Surgical Specialties, Bagdad / Iraq.
Sargon Shazo
Lecturer, University of Duhok / College of Dentistry, Iraq.
Faeza Aftan Zghair
Department of Pathology/ College of Medicine/ Aliraqia University, Bagdad / Iraq.

Abstract

Abstract 


 This study intends to compare the efficacy of traditional hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) in the assessment of primary oral squamous cell carcinoma and detection of lymph node (LN) occult metastasis.  The primary tumor sections of 80 patients diagnosed with primary OSCC and lymph nodes of 50 patients were treated with neck dissection were subjected to routine H&E staining and IHC (CK5/6) staining. Sections were analyzed for different pathological parameters and nodal metastasis.  Metastatic carcinomatous cells were observed in 14.3% of IHC sections compared to 13.5% of H&E sections. Except for tumor grade, statistical analysis for patients' age, gender, tumor diameter, tumor thickness (TT), and depth of invasion (DOI) revealed no significant correlation with lymph node status.  IHC is more sensitive to detecting lymph node occult metastasis than H&E staining in conventional procedures.


Keywords: biomarkers, IHC,  Squamous Cell Carcinoma, Tumor.

Article Details

How to Cite
Abdulkarem, A. M., Issa, S. A., Shazo, S., & Zghair , F. A. (2024). Impact of the Immunohistochemistry on appraisal of Oral Squamous Cell Carcinoma and Cervical Lymph Nodes Metastasis: Impact of the Immunohistochemistry on appraisal of Oral Squamous Cell Carcinoma and Cervical Lymph Nodes Metastasis. Journal of Medical and Oral Biosciences ( JMOB), 1(3), 41–51. https://doi.org/10.58564/jmob.49
Issue
Vol. 1 No. 3 (2024): Vol.1.(No.3).2024
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

The Journal of Medical and Oral Biosciences uses a Creative Commons Attribution (CC Attribution-ShareAlike 4.0) and its license of (CC BY-SA 4.0). This license allows the authors to hold ownership of the copyright of their articles.

Attribution-Share Alike 4.0 International License (CC BY-SA 4.0). 

Under the CC BY-SA 4.0 the authors are free to:
Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
No use, distribution or reproduction is permitted which does not comply with these terms.
https://creativecommons.org/licenses/by-sa/4.0/

https://creativecommons.org/licenses/by-sa/4.0/